production and quality control of 66ga as a pet radioisotope

نویسندگان

p. rowshanfarzad cyclotron & nuclear medicine department, nuclear research center for agriculture and medicine, karaj, iran

a.r. jalilian

m. sabet2

m. akhlaghi

چکیده

background: 66ga (t1/2=9.49 h, β+: 4.153 mev, γ: 511, 834, 1039, 2752 kev) has a wide range of applications in different fields of medical sciences. production of 66ga became one of our main interests, according to its increasing applications in nuclear medicine, particularly in pet imaging. materials and methods: 66 zn (p,n)66ga reaction was determined as the best choice for the production of 66ga, according to the present facilities and conditions. the bombardment was performed by 15 mev protons in cyclone 30-iba accelerator with a current intensity of 180 μa for 67 min. alice nuclear code and srim nuclear program were used to determine the optimum energy and target thickness. targets were prepared by electroplating of 66zn (>95%) on a copper backing. chemical processing was performed by a no carrier added method consisting of ion exchange chromatography and liquid-liquid extraction. anion exchange chromatography was used for the recovery of target material. quality control of the product was carried out in two steps of chemical and radionuclidic purity control. results: the activity of 66ga was 2.41 ci at the end of bombardment (e.o.b.) and the production yield was 12.04 mci/μah. the chemical separation yield was 93% and the yield of chemica l recovery of the target material was 97%. quality control tests showed a radionuclidic purity of more than 97% and the amounts of chemical impurities were in accordance with standard levels. discussion: our production yield was comparable with previous reports given in the literature. the chemical separation method used in this research was simple and brought up acceptable results. so, this process can be considered as one of the best choices for the production of 66ga. iran . j. radiat. res., 2004 2 (3): 149-158

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Production and quality control of 66Ga as a PET radioisotope

Background: 66Ga (t1/2=9.49 h, β+: 4.153 MeV, γ: 511, 834, 1039, 2752 keV) has a wide range of applications in different fields of medical sciences. Production of 66Ga became one of our main interests, according to its increasing applications in nuclear medicine, particularly in PET imaging. Materials and Methods: 66 Zn (p,n)66Ga reaction was determined as the best choice for the production of ...

متن کامل

[66Ga]Oxine complex preparation and stability as a possible PET radiopharmaceutical.

Background: Gallium-66 (T1/2= 9.49 h) is an interesting radionuclide that has potential for positron emission tomography (PET) imaging of biological processes in intermediate to slow target tissue uptake. Oxine has been labeled with this radioisotope in the form of [66Ga]gallium chloride for its possible diagnostic properties. Materials and methods: 66Ga was produced in the 30 MeV cyclotron (Cy...

متن کامل

Production, formulation, quality control and primary biological studies of [18F]KF for skeletal PET scanning [Persian]

[18F]KF, considered as a reference standard for positron emission tomography of the skeletal system, was produced by the bombardment of enriched water ([18O]H2O>95%) with high energy protons in NRCAM cyclotron. After the extraction of fluoride from enriched water as KF, and passing it through microbial filter and fine adjustment of acidity and osmolality, it was converted into an injectab...

متن کامل

Production, quality control and biological evaluation of 153Sm-TTHMP as a possible bone palliation agent

Introduction: Various bone palliative therapeutic agents have been developed and widely used for bone metastasis such as 153Sm-EDTMP. In this study, production, quality control and biodistribution studies of a newly developed therapeutic compound have been presented followed by imaging studies in wild-type rodents. Methods: 153Sm-TTHMP was prepared starting from 153<...

متن کامل

Production, Quality Control and Biological Evaluation of 166Ho-PDTMP as a Possible Bone Palliation Agent

Objective(s):In this study, 166Ho-1,2-propylene di-amino tetra(methy1enephosphonicAcid) (166Ho-PDTMP) complex  was prepared as a bone palliation agent. Materials and Methods:The complex was successfully prepared using an in-house synthesized EDTMP ligand and 166HoCl3. Ho-166 chloride was obtained by thermal neutron irradiation (1 × 1013 n.cm-2.s-1) of natural Ho(NO3)3 samples  followed by radio...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of radiation research

جلد ۲، شماره ۳، صفحات ۱۴۹-۱۵۸

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023